I presented a collaborative work with Didier Jean’s team (Functional genomics of solid tumor, Inserm Unit U1162, Hôpital Saint-Louis, Paris) about MPM heterogeneity characterization using molecular gradients. In our study, we show using a deconvolution approach, that molecular gradients bring new light on intra-tumor heterogeneity of MPM, leading to a reconsideration of existant MPM molecular classifications. We further show that this new way of thinking the pathology provides a significant contribution to clinical applications with implications in prognosis and therapeutic strategies, including immunotherapies and targeted therapies.
Posted by yunablum 
Yuna Blum 
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